Holzrichter served as chief operating officer of CME Group, the world’s leading derivatives marketplace, from 2014 to 2024. Prior to being appointed, Holzrichter held a succession of roles of increasing responsibility, including senior managing director of Global Operations from 2012 to 2014; managing director, Global Operations from 2007 to 2012; and director, Operations, from 2006-2007, among others. She has led the integration of global operations for a number of multi-billion-dollar mergers and acquisitions throughout her tenure.

Holzrichter serves on the board of the National Futures Association and she is a member of the Futures Industry Association and ChicagoFirst.

She previously served on DePaul University's Finance Advisory Board and DePaul's Center for Risk Management Advisory Board. She was named as one of Crain's Notable Women in Finance in 2019, one of the Illinois Diversity Council's Most Powerful and Influential Women in 2016, and was recognized as DePaul's Financial Woman of the Year in 2015.