Khandpur is President and Chief Executive Officer of Avient Corporation, a leading provider of specialized and sustainable materials solutions. He was also named chairman of the company’s board of directors in May 2025. 

Prior to joining Avient in in 2023, Khandpur served as president of the $9 billion Transportation & Electronics business group for 3M, a FORTUNE 200 global corporation operating in the fields of transportation, electronics, worker safety, health care, consumer goods and industry. During his 28-year career with 3M, he held a series of roles with increasing responsibility, including executive vice president, Transportation & Electronics business group, from 2019 to 2021; executive vice president, Electronics & Energy business group, from 2017 to 2019; senior vice president, Research & Development and Chief Technology Officer, from 2014 to 2017, among other roles.

Khandpur is a member of the Dean's Advisory Board, College of Science and Engineering, for the University of Minnesota. He served as a trustee for the University of St. Thomas from 2017 to 2021. He also served as a director for the 3M Foundation from 2012 to 2017 and prior to that was a director for 3M India in 2014.